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App Note: Nanotrap® Particles: A case study on novel antimicrobial peptide discovery


Nanotrap® Particles for Biomarker Discovery via Mass Spectrometry: A case study on novel antimicrobial peptide discovery

Conventional proteomic biomarker discovery methods typically involve fractionation processes such as high-performance liquid chromatography (HPLC) and proteolytic digestion of the intact peptides. In addition to relying on these labor and time intensive processes, conventional proteomic biomarker discovery is often challenged by the low abundance of the analytes of interest. The Nanotrap® particle technology addresses these problems and creates a straightforward and effective approach to biomarker discovery (Figure 1). This whitepaper provides a brief description of the Nanotrap® particle technology platform and presents an experimental protocol and results for enrichment of low abundance cationic peptides prior to mass spectrometry analysis.

Ordering Information

Nanotrap® Catalog Number:

· 33230 (Azure Protein Particles*)

· 33220 (Blue Protein Particles)

· 33210 (White Protein Particles)

· 33200 (Discovery Kit, includes all 3)

* “Azure” is new name for Purple particles

Scientific Support

Additional protocol details, variations for use, and technical and customer support are available upon request.

Contact Ceres Nanosciences

Phone 800-615-0418


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