Nanotrap Microbiome Particles

Nanotrap® Microbiome Particles are magnetic hydrogel particles designed to capture and concentrate low-abundance microbes (including bacteria, viruses, and fungi) from complex environmental, wastewater, and clinical samples, improving detection sensitivity across downstream workflows.

Overcoming Sample Limitations: Concentrating Microbes

Many labs struggle to detect microbial targets in complex samples such as wastewater, blood, and urine. Low target abundance combined with PCR inhibitors often results in weak signal or false negatives when using standard extraction workflows.

Nanotrap® Microbiome Particles address these limitations by physically capturing and concentrating intact microbes prior to extraction, improving recovery and enabling more reliable detection across downstream workflows. Key Advantages: -- Reduce false negatives: Concentration of low-abundance microbes increases detectable signal -- Remove inhibitors: Separation from complex matrices improves PCR and sequencing performance -- Enable detection at low levels: Improves recovery in samples near or below assay limits -- Process larger sample volumes: Efficiently concentrate microbes from mL-scale inputs -- Simplify workflows: Magnetic separation eliminates the need for centrifugation or filtration

Extensive Sample Type Compatibility

Environmental & Wastewater Samples

Wastewater
Surface waters
Blackwater
Sludge
Airplane lavatory fluid
Food wash

Clinical & Biological Samples

Urine
Whole Blood
Sputum
VTM/UTM
Saliva
plasma

Capture and concentrate low abundance microbes

Nanotrap® particles utilize affinity-based capture to bind and concentrate low-abundance microbes from complex samples, without relying on antibodies, enabling improved reagent stability and consistent performance.

Seamless integration with downstream workflows

Compatible with qPCR, dPCR, ddPCR, sequencing, immunoassays, and culture-based methods without requiring changes to existing workflows.

Consistent performance in complex matrices

Demonstrated performance across diverse and inhibitor-rich environmental and clinical sample types.

Eliminate centrifugation and filtration steps

Streamlines sample preparation by removing the need for centrifugation, filtration, or precipitation-based concentration methods, enabling more consistent recovery.

Expert technical support

Access dedicated Ceres technical support for guidance on workflow optimization, sample types, and implementation.

Microbiome Particles - Manufacturing lab image

SPEAK TO A SPECIALIST

Comprehensive Pathogen Coverage

Nanotrap® Microbiome Particles are designed for broad-spectrum utility across diverse microbial classes, including enveloped and non-enveloped RNA/DNA viruses, and Gram-positive/Gram-negative bacteria. Viral Targets Respiratory: SARS-CoV-2, Influenza A & B, RSV, and Coronaviruses (229E, OC-43). Global Health: Zika, Chikungunya, Dengue, Monkeypox, and Measles morbillivirus. Environmental Markers: Pepper mild mottle virus, Norovirus GII, and Hepatitis A. Bacterial & Parasitic Targets Enteric & Foodborne: E. coli, Salmonella enterica, Campylobacter jejuni, Listeria monocytogenes, and Clostridioides difficile. Clinical/STI: Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium. Fungi & Parasites: Candida auris, Cryptosporidium parvum, and Giardia lamblia.

Images of Nanotrap Microbiome Particles and Microbe Binding

Left to right:

Nanotrap Particles under scanning electron microscope (SEM )

Negative-stain transmission electron micrograph (25,000×) of Venezuelan equine encephalitis virus (VEEV) particles (white) captured and bound to Nanotrap Microbiome Particles (black).,

Scanning electron microscope image (5,000×) of Yersinia pestis (gram-negative bacteria; yellow) captured and bound to Nanotrap Microbiome Particles (red).