Compare PMMoV, crAssphage, and MT-CYB normalization markers for wastewater surveillance and learn how Nanotrap® technology supports reliable pathogen detection.

Article Link Publication: Twigg et al., Journal of Proteome Research (2026) Overview This study evaluated the performance of Nanotrap® Protein Enrichment Affinity Kits (PEAK) for mass spectrometry-based proteomic analysis of ascites fluid from patients with high-grade serous ovarian cancer (HGSOC). Because ascites contains abundant plasma proteins that mask low-abundance biomarkers, the authors investigated whether Nanotrap hydrogel particles could improve proteome coverage b

The Ceres PEAK platform represents a cost-effective complementary or alternative for plasma or VDBS proteomic analysis, and can be implemented as an optimized 2 hr plate-based single-day workflow. Inter-day validation confirms its robust reproducibility and strong cross-matrix correlation. Biological validation in ADRD samples confirms 25/31 AD-relevant biomarkers and pathway-level signal from VDBS — establishing a scalable, high-throughput platform for clinical proteomics.