Advancing Urinary Virome and Microbe Detection: Novel Particle Based Enrichment Workflow for Large Volume Urine Processing

Caryn Tyler
Jul 7
1 min read

Urine has traditionally been overlooked in viral diagnostics, with most research focusing on blood and respiratory samples. Advances in molecular testing and metagenomic sequencing have revealed that urine contains a diverse array of viral targets, including both eukaryotic viruses and bacteriophages. This growing evidence suggests that the urinary virome, much like the gut microbiome, may play a role in maintaining health and influencing disease. Despite these findings, current diagnostic methods, such as molecular assays and culture-based techniques, remain limited by low viral titers, inhibitory matrix components, and lengthy processing times. These challenges continue to hinder the comprehensive characterization of the urinary virome and its clinical relevance.

To address these challenges, we evaluated the use of Nanotrap® Microbiome B Particles to concentrate viral and bacterial microbes from urine. This application aims to enhance the detection and analysis of the urinary virome and microbiome across various urine sample volumes in a high-throughput setting.