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App Note: Nanotrap® Magnetic Virus Particles Capture and Concentrate Influenza A/B from Wastewater


Key Advantages

>> Can be used for wastewater surveillance of multiple viruses, including SARS-CoV-2, Influenza A and B.

> Detection of SARS-CoV-2 is not impacted by the presence of Influenza A and B in a sample.


Pathogenic viruses represent one of the greatest threats to human well-being. For example, the H1N1 influenza pandemic in 2009–2010 resulted in 60 million cases in 214 countries, and 150,000-575,000 estimated deaths. An outbreak of a novel coronavirus (SARS-CoV-2) was initially reported in China but has spread globally, with more than 270 million confirmed cases and more than 5 million deaths as of December 21st, 2021.

Municipal wastewater harbors a great variety of pathogenic viruses. Extensive research has been conducted on the persistence of human enteric viruses, transmitted via the fecal-oral route, in wastewater and in the aquatic environment. Wastewater surveillance is appealing because a single sample can ‘test’ a large population, it can enable detection from both asymptomatic and symptomatic individuals, and it can provide an indication of changing trends in population infection levels about 7 days ahead of clinical testing. CDC and HHS, in collaboration with agencies throughout the federal government, implemented the National Wastewater Surveillance System (NWSS) in response to the COVID-19 pandemic as a resource to help public health officials and communities utilize wastewater data to guide community level response and decision making.

There is an interest in using the infrastructure in place to track other common and potentially deadly pathogens. Nanotrap® Magnetic Virus Particles have demonstrated sensitive, rapid, and easy-to-use automated and manual methods for wastewater SARS-CoV-2 testing. In this application note, we show that Nanotrap® Magnetic Virus Particles can also capture influenza A and influenza B from wastewater without impacting the detection of SARS-CoV-2.


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