Nanotrap Particles for Febrile Illness-Causing Pathogens

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Use of Nanotrap® Particles for capture and enrichment of febrile-illness-causing pathogens, including Zika, Chikungunya, Dengue, and Influenza viruses

Presented at ASM CVS 2018

We assessed the utility of Nanotrap Microbiome Particles for capture and enrichment of febrile-illness causing pathogens, including Zika (ZIKV), chikungunya (CHIKV), dengue (DENV), and influenza (FLU) viruses. Through the use of qRT-PCR methods, we demonstrated that Nanotrap Particle type CN1030 provides at least 8-fold enrichment of ZIKV, CHIKV, and DENV from urine biospecimens. We demonstrated detection of ZIKV, CHIKV, and DENV at viral concentrations as low as 0.1 PFU/mL.