Mass spectrometry–based proteomic analysis is a powerful tool for biomarker discovery, but the detection of low-abundance proteins in complex biological samples such as plasma, serum, cerebrospinal fluid (CSF), and urine remains challenging due to high dynamic range and matrix-specific workflow constraints. The presence of abundant proteins, such as albumin, can mask lower-abundance analytes, limiting proteome depth and sensitivity for clinically relevant targets, including c

Tuberculosis (TB) remains a leading global health concern, causing approximately 1.4 million deaths annually.(1) Early and accurate detection of Mycobacterium tuberculosis in complex clinical samples, such as sputum, is critical for effective diagnosis and treatment. Traditional culture methods, while highly specific, are slow and labor-intensive. Molecular approaches such as qPCR and sequencing provide faster results but are often hindered by inefficient mycobacterial recove

INTRODUCTION Plasma proteomics is inherently challenging due to its extreme dynamic range, with a small number of highly abundant proteins dominating the sample and limiting detection of lower-abundance, biologically relevant proteins. Enrichment strategies are therefore needed to increase proteome depth without introducing excessive variability, cost, or workflow complexity. The Nanotrap® Protein Enrichment Affinity Kit (PEAK) - Discovery uses magnetic hydrogel particles to