Vector-borne diseases, including yellow fever, Zika, chikungunya, West Nile, and dengue, are posing increasing health risks globally.(1) There is a need for a simple and effective workflow that can be used with wastewater samples to capture and concentrate multiple microbes from a single sample. This experiment demonstrates that the Nanotrap® Microbiome Workflow effectively captures and concentrates low-abundance, vector-borne disease microbes from a single wastewater sample.

This study addresses these challenges by using Nanotrap® Microbiome B Particles to enhance Mycobacterium capture and concentration from sputum, offering a novel approach for TB detection.

The goal of the work was to assess genome coverage across several wastewater samples, evaluate the impact of DNase treatment on sequencing performance, and demonstrate a scalable, high-throughput solution for near real-time influenza surveillance.