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App Note: Capture and Concentration of SARS-CoV-2 from Viral Transport Medium

Updated: Sep 21, 2020


Key Advantages

> Nanotrap® Magnetic Virus Particles rapidly capture heat-inactivated SARS-CoV-2 from 1 mL of viral transport medium prior to RNA extraction.

> Nanotrap® Magnetic Virus Particles improve detection of SARS-CoV-2 using the IDT 2019-nCoV CDC qPCR Probe Assay across 4 logs of viral titers.


Coronaviruses are a large family of viruses that usually cause mild to moderate upper-respiratory tract illnesses in humans. Three times in the 21st century, coronavirus outbreaks have emerged from animal reservoirs to cause severe disease and global transmission concerns, including the most recent outbreak for COVID-19 disease, caused by SARS-CoV-21-3.

Nanotrap® Virus Particles have been shown to effectively capture and concentrate multiple strains of influenza, RSV, and coronavirus, thus enhancing detection of those viruses, even in co-infection scenarios4-7. Here, we show Nanotrap® Magnetic Virus Particles can capture and concentrate heat-inactivated SARS-CoV-2 from viral transport medium samples and demonstrate the impact of Nanotrap® particle preconcentration on assay sensitivity across a range of viral titers.


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