App Note: Rapid SARS-CoV-2 RNA Extraction from Universal Transport Medium Pooled Sample Mimics


APPLICATION NOTE SKU 44XXX


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Key Advantages


> Nanotrap® Magnetic Virus Particles enable RNA extraction of viral RNA from 4 mL UTM sample volumes in less than 20 minutes, representing a sample extraction method that is roughly 2X faster than column-based methods.


> Up to a 4-fold Ct value improvement for large volume pools across a range of viral titers, enabling detection of low viral load samples against a background of 7 negative samples in pooled sample mimics.


Introduction


As demand increases for testing for SARS-CoV-2, technologies that enable pooled testing for the virus will play a critical role in the efforts to remobilize the economy. Recent analyses from public health experts estimate that pooled testing could lower testing costs by up to three-quarters and could increase testing efficiency by as much as 400%, but concerns remain about reduced test sensitivity associated with pooling. Nanotrap® Virus Particles capture and concentrate multiple strains of influenza, RSV, and coronavirus, thus enhancing detection of those viruses, even in co-infection scenarios.


Here, we show that Nanotrap® Magnetic Virus Particles can capture and concentrate heat-inactivated SARS-CoV-2 from large volume universal transport medium samples that simulate patient sample pools. These results suggest that using Nanotrap® particles can alleviate sensitivity concerns associated with pooled sample testing.



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