Detection of LAM antigen from the urine of tuberculosis-infected children by Nanotrap® particles

Poster: Most diagnostic tests for tuberculosis (TB) depend on sputum samples which can be difficult to attain, making the diagnosis of TB in the young children challenging for treating physicians


Lipoarabinomannan (LAM) is the only WHO endorsed TB diagnostic biomarker test that can be detected in urine


In this study we aim to increase the sensitivity and diagnostic accuracy of one commercially available LAM test by incorporating a processing step using Ceres Nanotrap particles (Ceres Nanosciences, Manassas, VA, USA) to capture and concentrate LAM antigen in urine specimens from children with microbiologically confirmed TB and compare it with age-matched controls.


Processing urine with the Ceres Nanotrap particles increased the yield from Alere TB LAM strips from 9% to 54% among children with confirmed TB.





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