Nanotrap® Magnetic Virus Particles Concentrate Hepatitis A from Produce Wash Water and Wastewater

Nanotrap® Magnetic Virus Particles Capture and Concentrate Hepatitis A from Produce Wash Water and Wastewater


APPLICATION NOTE SKU 10XXX SKU 44XXX


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Key Advantages


> Nanotrap® Magnetic Virus Particles enable simple, automated methods for bio surveillance of a broad spectrum of infectious diseases including hepatitis A.


> The automated Nanotrap particle method is compatible with several large volume sample types including produce wash water and wastewater.


> The automated Nanotrap particle method offers equivalent or better hepatitis A viral detection from wastewater samples, as compared to an HA filtration method.


Introduction


Hepatitis A is an acute inflammatory liver disease which results from infection by the hepatitis A virus (HAV). It is faeco-orally spread, and its severity is age dependent. Recently, cases of acute hepatitis of unknown origin among young children have been reported from 12 countries around the world. Routine food safety testing can be used to effectively identify HAV present on foods, while wastewater surveillance for HAV can provide an indication of infection levels and affected geographical locations.


Municipal wastewater harbors a variety of pathogenic viruses. Extensive research has been conducted on the persistence of human enteric viruses, which are transmitted via the fecal-oral route, in wastewater and in the aquatic environment. Wastewater surveillance is appealing because a single sample can ‘test’ a large population, it can enable detection from both asymptomatic and symptomatic individuals, and it can provide an indication of changing trends in population infection levels about 7 days ahead of clinical testing. CDC and HHS, in collaboration with agencies throughout the federal government, implemented the National Wastewater Surveillance System (NWSS) in response to the COVID-19 pandemic as a resource to help public health officials and communities utilize wastewater data to guide community level response and decision making.


There is an interest in using the infrastructure in place to detect and monitor other common and potentially deadly pathogens. Nanotrap Magnetic Virus Particles have demonstrated sensitive, rapid, and easy-to-use automated and manual methods for wastewater SARS-CoV-2 testing. In this application note, we show that Nanotrap Magnetic Virus Particles can also capture HAV from wastewater samples and from simulated agricultural produce wash samples.









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